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Feasibility of Oral Prenatal Probiotics against Maternal Group B Streptococcus Vaginal and Rectal Colonization

      Abstract

      Objective

      To examine the effect of an oral prenatal probiotic on group B Streptococcus (GBS) colonization and to demonstrate the feasibility of a larger randomized controlled trial.

      Design

      This pilot study was an open‐label, two‐group quasi‐experiment.

      Setting

      An urban central city nurse‐midwifery and wellness center serving a diverse population.

      Participants

      Ten pregnant participants received the oral probiotic (Florajen3) taken once daily, and 10 participants served as controls.

      Methods

      A questionnaire on dietary practices, vaginal cleansing, sexual history, and symptoms and GBS colony count samples were taken at 28‐, 32‐, and 36‐weeks gestation.

      Results

      Participants in the probiotic group reported no adverse events or minor side effects; one half reported improved gastrointestinal symptoms. Although two women in each group had positive qualitative prenatal GBS cultures at 36 weeks, the probiotic group participants had lower quantitative GBS colony counts. The eight GBS negative averaged 90% probiotic adherence compared with two GBS positive women who averaged 68%. Yogurt ingestion was inversely related (p= .02) to GBS colonization.

      Conclusions

      Prenatal probiotic therapy has the potential to reduce GBS colonization. The potential of the probiotic intervention appears to be linked to daily adherence. A controlled clinical trial with a larger, adequately powered sample is feasible and justified.

      Keywords

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      Biography

      Lisa Hanson, PhD, CNM, FACNM, is an associate professor and the Associate Director of the Nurse-Midwifery Program, College of Nursing, Marquette University, and a clinical associate professor, Aurora Sinai Midwifery and Wellness Center, Milwaukee, WI.

      Biography

      Leona VandeVusse, PhD, RN, CNM, FACNM, is an associate professor and the Director of the Nurse-Midwifery Program, College of Nursing, Marquette University, Milwaukee, WI.

      Biography

      Megan Duster, MT (ASCP), is a senior research specialist and manager of the Infectious Disease Research Laboratory, University of Wisconsin School of Medicine and Public Health's Division of Infectious Disease, Madison, WI.

      Biography

      Simone Warrack, BS, is a research specialist at the University of Wisconsin School of Medicine and Public Health Infectious Disease Research Laboratory, Madison, WI.

      Biography

      Nasia Safdar, MD, PhD, is an associate professor, Department of Medicine and Infectious Disease, University of Wisconsin School of Medicine and Public Health, and associate chief of staff for research, William S. Middleton Memorial Veterans Hospital, Madison, WI.